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Title
[Physiopathology of pertussis encephalopathy. Prophylaxis. Pathogenesis of the "reaction" against intramuscular pertussis vaccine. Vaccination with "shield"]
Original Title
Fisiopatologia dell'encefalopatia pertussica. Profilassi. Patogenesi delle "reazioni" da vaccino antipertosse intramuscolo. Vaccinazione con "copertura".
Author
Fiore D
Source
Pediatr Med Chir, 13: 3, 1991 May-Jun, 265-6
Abstract
The specific local and humoral immunological situation of the child, by permitting or not (+/- specific IgA-S) the passage of the Bordetella toxins to the bloodstream and the formation or not (+/- specific circulating IgG) of Circulating Immune Complexes (CIC), brings back to Type III Immunoreactions the pathogenesis of the pertussis encephalopathy and the reactions provoked by intramuscular vaccine. Since the antihistaminics and antiserotoninics can prevent the CIC precipitation, the Author believes that this would imply the indication to the usage of antihistaminics or antiserotoninics to prevent both the neurologic complications of the illness and the systemic reactions to the intramuscular vaccine.